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Fighting Low Estradiol Symptoms That Affect Your Testosterone Replacement Therapy Treatment

Low Estradiol Symptoms

Hormones—the human body is full of them.

Even though we focus on the treatment of low testosterone at TCT, testosterone is not the only hormone that you should be paying attention to if you’re getting testosterone replacement therapy treatment. Just as women have a small amount of testosterone in their body, men have a small amount of estrogen in their body. Estrogen comes in many forms, but estradiol is the most common form in the body.

Just as low testosterone symptoms will make you miserable enough to seek treatment, low estradiol symptoms can do the same. Estradiol is a form of estrogen you need to monitor if you’re receiving hormone replacement therapy. Because high or low levels of estradiol can cause a variety of unpleasant symptoms during testosterone replacement therapy, talk to your medical provider about measuring this critical hormone.

So what exactly does estradiol do? Its effects in women are well studied because it’s such an important hormone for them; however, it plays a significant role in male health as well. According to this study, estrogens play a role in the following bodily functions in men:

  • sex interest
  • brain functions
  • bone maturation
  • regulation of bone resorption
  • lipid metabolism
  • skin metabolism

If estrogen is playing this kind of a role in the function of your brain (not to mention these other important organs!), you definitely don’t want to get rid of it completely. Just like with testosterone (or any hormone), the goal is to get your levels to that Goldilocks point—not too high and not too low.

Specific Low Estradiol Symptoms to Look Out For

Just like low testosterone, low estradiol symptoms can sometimes look like the symptoms of other diseases. High estradiol symptoms can sometimes be just as bad. Keep your eyes open for the following symptoms and talk to your medical care provider about options to combat estradiol issues.

Low Estradiol Symptoms

You can check out this website for a full list of low estradiol symptoms, but here are some of the more common ones to watch out for:

  • Fatigue
  • Oversleeping
  • Sleeping too often
  • Erectile dysfunction
  • Water retention
  • Anxiety
  • Depression
  • Irritability

High Estradiol Symptoms

High estradiol also has some similar symptoms to watch for:

  • Water retention
  • Excessive sweating
  • Insomnia
  • Night sweats
  • High blood pressure

Talk to Your Medical Care Provider if You’re Experiencing These Symptoms

Because these symptoms are common to many different diseases and disorders, it’s very important that you discuss them with your medical care provider to see if low estradiol is behind the way you’ve been feeling.

If you’re interested in getting tested for estradiol levels in addition to testosterone levels, click here to set up a free consultation today. We’ll check your hormone levels and figure out exactly what’s been holding you back.



(Augie) Juan Augustine Galindo Jr. MPAS, PA-C

(Augie) Juan Augustine Galindo Jr. MPAS, PA-C started his career in healthcare as a fireman/paramedic in West Texas where he served on the Midland Fire Department from 1998-2004.   He became interested in testosterone treatment after seeing how hormone replacement doctors helped those suffering from low testosterone.   After graduating from the Texas Tech Health Sciences Center Physician Assistant Program, he moved to DFW where he currently lives with his wife and three children.


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  5. Richard Lovato on 10/14/2017 at 3:17 pm

    Question for you guys. I’m currently on trt, no AI no hcg .. currently my last blood draw I had upper 900 testosterone levels but completely crashed estridol .. I’m suffering from the low e sides (acne , mood swings, insomnia) how is this possible not to convert a little to estrogen? . What can I do with my doc to get my E levels into normal ranges . Hcg? Is this common? What should I ask my doc to test on my bloods .. she is clueless

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