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Low T: What Does Depressed Mood Really Mean?

Low T can lead to changes in your mood. This has been referred to as moodiness, irritability, mood swings, dysthymia, low sense of well-being and finally, depression. Including true clinical depression as a symptom of low testosterone, however, would be a gross overstatement or at the very least, presumptuous.

While there is a lack of clinical data that formally establishes a cause and effect relationship between Low T and clinical depression, it is well documented that irritability and other negative mood alterations are strongly linked with sub-normal levels of testosterone.

These mood changes associated with hypogonadism (Low T) can manifest in a plethora of ways. Perhaps you are experiencing mood changes that sap your motivation or prevent engagement in those activities from which you previously drew great satisfaction and enjoyment. It may be that by the end of your workday (when testosterone levels are approaching their lowest point) your deteriorating mood might shorten your “fuse” at home with your spouse or children.

Irritability vs. Depression

Irritability is an often seen symptom of Low T and is one way that “depressed mood” is often characterized. Depending on your levels, it may be a fairly constant feeling or it may slowly worsen throughout your day. Just being irritable can have a profound effect on your relationships and therefore your life. That hair trigger that comes along with being brooding and petulant can lead to arguments with your mate or resentment between you and your loved ones. In this way, your bad mood can poison not just you, but those around you as well.

Having a healthy and balanced self-esteem is vitally important to one’s self image and is closely linked with your overall sense of well-being. While this is definitely a “soft” symptom, and one difficult to define or quantify, it is simply intuitive that if you feel better about yourself you will be more likely and able to perform to the best of your individual abilities. People who feel better, do better.

What About TRT And “Roid Rage”?

When discussing mood changes and Low T, or the effects of testosterone in general, questions about “roid rage” are often raised. With recent stories like that of Oscar Pistorius or the claims of the vacillating Charlie Sheen that testosterone was to blame for his erratic behavior, it is natural to wonder what kind of “mood elevation” might be expected with testosterone replacement therapy (TRT).

Steroid abuse is responsible for the phenomenon known as “roid rage”. The levels that are reached with the abuse of anabolic substances are achieved with doses that are 5 – 15 times higher (or more) than what doses used for testosterone replacement purposes. That being said, this hyper-aggressive state is not seen in patients undergoing TRT that is ethically and responsibly managed.

Multiple studies indicate that when Low T is treated appropriately, it can stabilize and improve the overall mood and sense of well being of the patient. This can obviously be very subjective, but in a clinical setting we have seen the moods of many, many men respond favorably and significantly to TRT.

What Can Be Done About Depressed Mood Caused By Low T?

As with anything, each person is unique and each treatment and response may vary. Ultimately, what should matter to you is how you feel and how your mood might respond to treatment. Low energy levels and decreased libido are certainly the hallmarks of Low T, but many other aspects of your life can be affected. Depressed moods have negative effects on your relationships with family, friends and co-workers. Irritability can rob you of joy and decrease your quality of life. These changes undoubtedly also contribute decreased productivity and motivation.

Low T is treatable. If your mood is suffering because of low testosterone levels there is a strong possibility that these symptoms could improve with treatment. If you feel like a more irritable and depressed version of who you once were, we urge you to CONTACT US today to talk with one of our experienced and knowledgeable providers.



(Augie) Juan Augustine Galindo Jr. MPAS, PA-C

(Augie) Juan Augustine Galindo Jr. MPAS, PA-C started his career in healthcare as a fireman/paramedic in West Texas where he served on the Midland Fire Department from 1998-2004.   He became interested in testosterone treatment after seeing how hormone replacement doctors helped those suffering from low testosterone.   After graduating from the Texas Tech Health Sciences Center Physician Assistant Program, he moved to DFW where he currently lives with his wife and three children.


  1. alana on 02/25/2016 at 11:02 am

    can low t make my husband not have the deep feelings like he used to for me? he says he still loves me but the passion he once had is not there. he keeps telling me it’s not me and that he needs to find it again. it’s like he can’t be in same room as me or even look at me this is breaking my heart as he is my world and I never ever would
    have thought we would
    be going thru something like this. help me understand

    • Augie Galindo on 02/25/2016 at 2:25 pm


      Thank you for reaching out and commenting. I understand how difficult these things can be, and I am sorry that you and your husband are going through this. If you would, please forgive some assumptions I must make to answer this question effectively. Keep in mind that their are a multitude of things that could be affecting your husband in this way, but being that we focus on hormonal health, let me address this from that vantage point.

      Testosterone deficiency, and the often resultant low libido and sexual dysfunction, can absolutely exert this type of effect on patients (men OR women). Also, it’s important to remember that if libido, and especially erectile function is compromised, this can lead to mounting anxiety over the potential of a failure to perform. This often initiates a vicious cycle that is both difficult to talk about, and difficult to manage personally.

      Best regards,
      Augie Galindo MPAS, PA-C
      Testosterone Centers of Texas | Founding Partner

  2. Yashwanth on 02/07/2017 at 12:08 am

    Hello myself yashwanth and am 20years old and from and since my puberty I had almost all the symptoms of low t now finally I took out my blood reports and both my testosterone and free testosterone were low my total test came around 212ng/dl so now my doctor as put me on replacement therapy and gave me testosterone undeconate cernos and said me to repeat the blood work after six weeks.Itsbeen three weeks after my shot and now again am feeling tired,mood swings,depressed and what ever I eat stores as fat and how much ever I workout and eat clean I don’t get muscle mass or gain muscle.Am I fine?Is my condition treatable am very much worried and am just 20years please help me out doctor your reply will be more valuable.Thank you…

    • Augie Galindo on 02/07/2017 at 11:30 am


      The main thing I see the need for is some watchful waiting. It is too early to grade your response at this point, and muscular gains are probably a poor metric for TRT. It’s not something I necessarily target for my patients. Mood issues may point to a need for closer monitoring of your estrogen levels.

      Best regards,
      Augie Galindo MPAS, PA-C
      Testosterone Centers of Texas | Founding Partner

      • Yashwanth on 02/07/2017 at 1:09 pm

        Yes I will wait on watch out and to add on my estrogen levels and my lh was fine but my fsh was low again thank you for your reply means a lot

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