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Side Effects of Testosterone Injections in Women

What are the side effects of testosterone injections in women? First, it is important to establish a baseline understanding of side effects and medical treatment. Every form of medical intervention comes with possible side effects and inherent risks. Testosterone Replacement Therapy is not an exception.

Minimizing Side Effects of Testosterone — Injections in Women (and Men)

There is a good reason why we suggest testosterone injections, in women and men both, over other forms of Testosterone Replacement Therapy (TRT). This form of TRT is both the most effective and the least likely to cause side effects.

side effects of testosterone injections in women

Injections allow us to be extremely precise with the dosage we recommend for you. Creams and gels are unreliable, and pellets come with a slew of unwanted side effects.

We’ve concluded that, with improved dosing, injections promote marked symptomatic improvement and a reduction in potential untoward side effects.

Therefore, we favor injections over any other form of testosterone replacement therapy — we desire to administer an adequate amount of testosterone to relieve your symptoms, but in a regulated and controlled manner to ensure your dose is neither too high nor too low.

Other Methods of Testosterone Supplementation

Here are our thoughts on the other possible methods of testosterone supplementation and their side effects:

Topicals and Gels

Topicals and gels are generally a fallback option — we avoid them when we can for these reasons:

  • They often are not absorbed, failing to provide any relief of your symptoms
  • They can be transferred to those you are in physical contact with
  • They are costly and are rarely covered by insurance

Topicals and gels also still have the same possible side effects of testosterone injections. In women, testosterone replacement therapy doses need to be exact — there is little room for error — so we favor injections perhaps even more so than we might with men.

Subdermal Pellets

Subdermal pellets come with their own host of side effects that differ markedly from testosterone injections. In women, avoiding these potentially serious problems is crucial.

  • Pellets generally do not work as advertised
  • Pellets can be extruded (fall out) from your body
  • Pellets do not have a proper time-release mechanism, leading to testosterone levels that may be too high for the first month (inviting risk) and levels that are too low months later
  • Some pellets may not be FDA approved or covered by insurance

As outlined above, the route of delivery can lead to a significantly different clinical outcome and strongly mitigate side effects — testosterone injections (in women) are preferred for this reason.

Testosterone Injections for Women (and Men) Are Probably the Ideal Option

Here’s why we favor weekly administration of testosterone injections for women (and men). Testosterone injections:

  • Increase testosterone levels quickly
  • Improved ability to maintain testosterone in a therapeutic range
  • Dose can be easily adjusted during the course of treatment
  • Improved outcomes and minimal risk

All methods of administering supplemental testosterone have limitations, but, by utilization of injections, we are better able to monitor your body’s hormone levels and ensure that your testosterone remains in a healthy state.

What Are the Side Effects of Testosterone Injections in Women?

During the course of treatment, levels need to be monitored and carefully controlled.

The side effects of excessive testosterone in a woman are the same for every method of testosterone administration (though very rare and predominantly evident with inappropriate and excessive testosterone administration):

  • Acne
  • Oily skin
  • Male-pattern hair growth
  • Hoarse or deepened voice (rare, occurring only with excessive dosing)
  • Enlarged clitoris (also an uncommon result of excessive dosing)

As we said earlier, the advantage of regularly scheduled injections is that we can accurately monitor what is being administered and absorbed (which cannot be done with topicals or pellets).

The other methods, such as pellets and many topicals, are both imprecise and were designed for men.

Patches, gels, or pellets also may not work for you because the doses assume both men’s higher body weight and a higher level of natural testosterone.

Injections are the most accurate method available — they give you the best chance to get relief from low testosterone while still mitigating side effects.

Watch the Video to Get More Information

If you’re considering TRT (Testosterone Replacement Therapy), but still have some reservations or concerns about potential side effects, we recommend you click the button to watch our video about why we advocate the use of injections for TRT over any other method.

Watch the Video



Glenn Steponaitis, PA-C

Glenn Steponaitis, PA-C began his healthcare career nearly 20 years ago as a medical technician at Seton Medical Center while concurrently earning a Bachelor of Arts degree in Biology at the University of Texas in Austin.   His interest in medicine lead him down the path of becoming a certified Physician Assistant and achieving a Bachelor of Science degree in this field from the University of Texas Southwestern Medical Center at Dallas.   Following completion of his schooling, Glenn started a 10 year career in the field of Gastroenterology and Hepatology, and in 2010 he began focusing on the medical management of those suffering from symptoms caused by low testosterone after witnessing hormone replacement doctors help Low T sufferers.

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