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TRT and Blood Pressure Concerns? The Solution Is Simpler Than You Might Expect

When there’s a discussion about the benefits and side effects of testosterone replacement therapy (TRT), blood pressure risks are often mentioned.

Does TRT raise blood pressure? Should you be concerned?


This is the effect that TRT can have on your blood pressure — learn more.

Testosterone replacement therapy is a potent medical treatment, not a simple vitamin supplement — there are potential risks with every drug treatment or therapy the medical community provides. Supplemental testosterone is no exception.

These days, the medical community has a clear understanding of the connection between TRT and blood pressure increases — there’s also a very simple solution should a problem develop.

That means there’s very little risk of causing high blood pressure with TRT if your health is carefully monitored during treatment.

However, somebody has to be on the lookout for the warning signs of potential problems and make course corrections related to dosing and treatment along the way.

At Testosterone Centers of Texas, your health and safety come first. That’s why careful monitoring and frequent blood tests are considered to be of the utmost importance.

TRT and Blood Pressure Concerns — What’s the Problem?

If you’re taking supplemental testosterone without proper supervision or precautions, the risks of high blood pressure can definitely increase — why is that?

Testosterone (and other hormones) cause a variety of reactions within your body.

Relating this fact to your cardiovascular system, the chain of bodily reactions begins when testosterone suppresses a peptide hormone called pepcidin. Produced in your liver, pepcidin helps your body regulate iron absorption.

When pepecidin is suppressed, iron stores in your blood increase.

Increased iron in the blood signals your bone marrow to work harder at its job — producing more red blood cells.

Red blood cells carry hemoglobin, and hemoglobin transports oxygen to your organs.

More oxygen can be a good thing, but an overabundance of red blood cells can become counterproductive and even harmful over time.

Red blood cells represent the solid component of blood. They’re suspended in the liquid component of your blood: Plasma.

An increase in solid blood cells suspended in the same amount of liquid plasma leads to thickening or increased viscosity of your blood — a condition called erythrocytosis or polycythemia.

Too often, patients’ hematocrit levels aren’t monitored carefully, and these conditions are allowed to persist for a much longer duration than would be considered safe.

Left undiscovered, this increased blood viscosity leads to strain on your cardiovascular system — that can lead to heart disease.

What’s the Solution to TRT and Blood Pressure Risks?

We know that increased blood viscosity and the resulting tendency to form clots is a risk.

However, studies purporting that TRT causes this risky condition fail to answer some very obvious questions: Were any preventative measures were taken? Was anybody monitoring the overall health of these patients during the course of treatment?

Simple preventative measures should be taken, the first of which is to carefully monitor our patient’s hematocrit levels (the concentration of red blood cells suspended in the blood plasma) through frequent blood testing.

By keeping a close eye on blood viscosity, action can be taken before unnecessary strain on your circulatory system occurs — the second preventative measure, which is called a phlebotomy.

In simple terms, excess blood is removed in order to reduce viscosity and relieve potential exertion — donate some blood to a good cause.

It’s really that simple.

Does TRT Lower Blood Pressure?

This is an interesting question. TRT and blood pressure are definitely related, but TRT doesn’t directly lower blood pressure.

If you’re suffering from the symptoms of low testosterone, you’ve probably been feeling less than your best for a while — TRT treatment can help you feel better. That makes it easier to exercise and make better dietary decisions.

In that way, you can develop a healthier lifestyle that certainly can lower your blood pressure.

Frequent monitoring of your overall health (including your hematocrit count) can provide early warnings for a wide variety of health concerns.

Still Concerned About the Effects of TRT on Blood Pressure?

It’s understandable that you still have questions about testosterone replacement therapy (TRT) — blood pressure irregularities being one possible risk.

The investigation phase that involves expressing concerns and asking questions is a critical step in the decision to address a health problem — low testosterone and TRT are not exceptions.

Both your safety and peace of mind receive the highest level of attention at Testosterone Centers of Texas. In that vein, we invite you to learn more about possible side effects of TRT (blood pressure concerns included) and what we do to prevent them by clicking the button below.

How We Prevent Side Effects



Glenn Steponaitis, PA-C

Glenn Steponaitis, PA-C began his healthcare career nearly 20 years ago as a medical technician at Seton Medical Center while concurrently earning a Bachelor of Arts degree in Biology at the University of Texas in Austin.   His interest in medicine lead him down the path of becoming a certified Physician Assistant and achieving a Bachelor of Science degree in this field from the University of Texas Southwestern Medical Center at Dallas.   Following completion of his schooling, Glenn started a 10 year career in the field of Gastroenterology and Hepatology, and in 2010 he began focusing on the medical management of those suffering from symptoms caused by low testosterone after witnessing hormone replacement doctors help Low T sufferers.

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