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When Will Testosterone Replacement Therapy (TRT) Kick In?


The symptoms of low testosterone (Low T) gradually progress with the subtle changes slowly affecting you physically and psychologically, and testosterone therapy is a safe and effective way to treat them. It is not uncommon for patient who are beginning TRT to seek the quickest methods to correct the problems. So, naturally, one of the first questions asked is about how quickly treatment will begin working?

The Timeline of Testosterone Therapy Response 

 As with any therapy, there are several factors which will influence how quickly you respond to treatment:

  • Underlying medical conditions which can influence energy levels, sexual interest and cognitive function include cardiovascular conditions and diabetes, and depression
  • Level of testosterone at onset of treatment, or how “low” you are when you start TRT
  • The specific complaints being addressed, such as low energy levels, loss of interest in sex, erectile dysfunction, depression, changes in body fat, etc.
  • Compliance to treatment regimen and quality of oversight

Many of the symptoms suffered as a result of low testosterone, begin to improve during the first month of therapy. The initial benefits of low testosterone injections, or TRT often continue to build as treatment is continued. For instance, men who are dealing with a loss of interest in sexual activity will typically claim to notice an increase in their drive within three weeks, and often find a return to their full level of activity after six weeks. Depressive moods may show improvement after three to six weeks, but the greatest effects are not realized until 18 to 30 weeks of TRT.


Your symptoms may diminish within different periods, especially if you are dealing with more than one issue. You may notice that you begin to gain your sexual interest back early, however, problems erectile function due to low testosterone may not respond for six months or longer.


 If you are suffering from a medical condition such as diabetes, your response to TRT may be delayed or minimal without having these health concerns under control. Having a thorough medical examination to identify and address any underlying health issues is extremely important in developing the best approach to low testosterone treatment.


When undergoing TRT it is important to remain consistent and to comply with sound medical guidance. There are real complications that can occur with therapy, so your symptoms and the potential for side effects need to be monitored carefully. Any questions, or concerns, should be directed to your care professionals in order to allow for the best response to testosterone therapy.




(Augie) Juan Augustine Galindo Jr. MPAS, PA-C

(Augie) Juan Augustine Galindo Jr. MPAS, PA-C started his career in healthcare as a fireman/paramedic in West Texas where he served on the Midland Fire Department from 1998-2004.   He became interested in testosterone treatment after seeing how hormone replacement doctors helped those suffering from low testosterone.   After graduating from the Texas Tech Health Sciences Center Physician Assistant Program, he moved to DFW where he currently lives with his wife and three children.

1 Comment

  1. Why Beer Isn’t So Manly on 01/27/2016 at 1:16 pm

    […] what the problem is, many men want to know what caused it. “How did I get Low T?” and “how long does it take for testosterone therapy to work?” are among the first questions patient’s often […]

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