Research Connects COPD and Low Testosterone Diagnosis and Treatment Options

Chronic Obstructive Pulmonary Disease (COPD) is the general medical term for a series of progressive lung diseases that includes emphysema and chronic bronchitis. These diseases cause severe breathing difficulties, weakness, and fatigue.

The primary cause is a history of tobacco smoking, and genetic predisposition seems to be a significant factor as well.

It’s estimated 24 million Americans have COPD, and millions more may be undiagnosed or misdiagnosed with asthma. COPD is one of the leading causes of death worldwide, and deaths resulting from COPD are projected to rise through 2030. There currently is no cure for COPD.

There’s more bad news—medical research shows that men with COPD are likely to also suffer from low testosterone.

A man in a gray sweater uses an inhaler to get relief for a breathing problem. COPD has been linked to low testosterone.

COPD and Low T: What’s the Connection?

It is suspected that chronically low oxygen levels, a direct result of the damage this disease inflicts on patients’ lungs, impair the body’s ability to produce testosterone and other hormones that are necessary for optimal health.

On top of that, conventional COPD treatment methods may drop testosterone levels even lower. According to COPD News Today:

“Men with COPD tend to experience shortness of breath, leading physicians to prescribe them long-term steroid-based medications. While these medications help treat pulmonary symptoms, they are also associated with testosterone dysfunction.”

Low T May Worsen COPD Symptoms

If you have been diagnosed with COPD and are experiencing significant symptoms, you should know that Low T may be exacerbating the problem. The chronic shortness of breath and low oxygen levels characteristic of COPD usually contribute to fatigue, a resistance to exercise, and deterioration of muscle tissue.  

Increased fatigue, loss of lean muscle mass, and an early onset of frailty are common symptoms of low testosterone.

Men suffering either of these conditions are likely to feel much less than their best, and, if they’re suffering from both simultaneously, they’re likely to feel much older than they actually are.

Research: TRT Could Benefit Men With COPD

Although few studies have directly examined the co-occurrence of COPD and Low T, the existing research suggests that Testosterone Replacement Therapy (TRT) may have a beneficial effect on the respiratory health of men with COPD.

One study of interest examined approximately 700 men with COPD who had undergone TRT. The researchers’ analysis showed that the TRT recipients had fewer respiratory hospitalizations compared with those who hadn’t received TRT.

To be more specific, middle-aged subjects who underwent a TRT regimen showed a 4.2% decrease in respiratory hospitalizations compared with those not treated with TRT, and older subjects utilizing TRT experienced 9.1% fewer respiratory hospitalizations than those subjects receiving a placebo.

These findings suggest that TRT can slow the progression of COPD in many patients.

Dr. Jacques Baillargeon, one of the authors of the study had this to say about the results:

“We don’t know if the improvement was related to increased skeletal muscle, reduced hypoxemia, increased mobility, decreased inflammation, or some other reasons, yet it is possible that TRT slows progression.”

A second study showed that TRT could increase the lean body mass and strength in men with severe COPD coupled with low testosterone levels, particularly when combined with resistance training. Supplementary testosterone produced increased leg extensor strength and resistance to fatigue, important for simple everyday living but compromised in men with COPD and low testosterone. However, whole-body exercise endurance was not enhanced.

Also, the respiratory muscles didn’t show significant improvement, which was a surprise. However, it’s reasonable to assume that those muscles directly involved in breathing already may have reached their peak efficiency—COPD sufferers exert enormous effort to take each breath.

Low T and COPD: TRT May Provide Treatment Options

Men who have both COPD and low testosterone are suffering from compounding factors that have joined forces to rob life of it’s joy and vitality, but many men in this category are unaware that their symptoms and ill health are partly caused by Low T.

The silver lining to that dark cloud is that treatment is available.

Read the Comprehensive TRT Guide


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(Augie) Juan Augustine Galindo Jr. MPAS, PA-C

(Augie) Juan Augustine Galindo Jr. MPAS, PA-C started his career in healthcare as a fireman/paramedic in West Texas where he served on the Midland Fire Department from 1998-2004.   He became interested in testosterone treatment after seeing how hormone replacement doctors helped those suffering from low testosterone.   After graduating from the Texas Tech Health Sciences Center Physician Assistant Program, he moved to DFW where he currently lives with his wife and three children.


  1. Ernie McCall on 10/30/2022 at 8:57 pm

    I suffer from all of the abovemy age a young 78 yrs old .I have had no energy and fighting for breath for 2yrs now I worked full-time to the age of 75yrs of age I would like to try the Testosterone injections I was known as a workaholic. I just need help before it’s too late. Thank you .

    • Hello Ernie!

      I recommend starting with your “eyes wide open”. Find someone who will look at baseline numbers and ease into therapy. TRT can have powerful effects, especially as we age. The quality of the care will be a chief determining factor in whether that impact is positive or negative.

      Best regards,

      Augie Galindo MPAS, PA-C
      Testosterone Centers of Texas | Managing Partner

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