Semaglutide: Promising Potential for Weight Loss and Improved Cardiac Health

Fairly recently, semaglutide has emerged as a breakthrough medication in the management of type 2 diabetes, but there’s more to the story. 

With obesity and heart disease epidemics affecting millions worldwide, the positive health benefits of semaglutide present a glimmer of hope for many struggling with weight management and cardiovascular health.

This innovative drug, semaglutide, has shown significant potential to help individuals achieve sustained weight loss while simultaneously reducing the risk of cardiac arrest. 

A female doctor in a blue blouse and white lab jacket is pictured from the shoulders to the waist, holding out a stethoscope with her left hand. Semaglutide may improve cardiac health.

Semaglutide and Cardiac Health: Weight Loss 

Semaglutide belongs to a class of medications known as GLP-1 receptor agonists, which help to regulate blood sugar levels, and it has also been found to aid in significant, sustainable weight loss in individuals with or without diabetes when used as an adjunct to diet and exercise. 

As a GLP-1 receptor agonist, semaglutide mimics the action of incretin hormones, which regulate glucose, insulin, and satiety. When the GLP-1 receptors are activated, semaglutide increases insulin secretion, leading to better glucose control, reduced appetite, and slowed stomach emptying. These combined effects contribute to weight loss and subsequent improvements in cardiometabolic markers.

(Learn about semaglutide and weight loss.)

Semaglutide and Cardiac Health: What the Research Shows

In one study, participants treated with semaglutide achieved an average weight loss of 15-20% of their initial body weight over a 68-week period. The maintained reduction in weight translates to significant improvements in overall health through normalized blood pressure and cholesterol levels, on top of the expected improvements to insulin sensitivity. 

Multiple trials have indicated that semaglutide can significantly reduce the risk of major cardiovascular events, including: 

  • Heart attack
  • Stroke
  • Mortality from long-term cardiovascular issues

What seems to be of the greatest importance is semaglutide’s positive effect on cardiac health, especially those who suffer from established cardiovascular disease (with or without co-occurring type 2 diabetes). 

Initial results from the SELECT clinical trial, which observed 17,000 overweight or obese people with established cardiovascular disease (CVD), but no diabetes, indicate:

Semaglutide reduced major adverse cardiovascular events (MACE) by 20% when given to patients, compared with those receiving placebo.

These findings suggest that semaglutide not only aids weight loss efforts but also has direct cardioprotective effects, making it an effective tool in combating the growing prevalence of poor cardiac health.

Semaglutide and Cardiac Health: Consult Your Medical Provider

Semaglutide offers an exciting advancement in the field of weight management and cardiovascular health. The potential benefits of sustained weight loss, improved diabetes control, and reduced risk of cardiac arrest provide hope for millions of individuals worldwide. 

However, it is crucial to approach the use of semaglutide as a solution within an integrated approach, in cooperation with your medical practitioner, that encompasses:

  • A healthy diet
  • Regular exercise
  • Other general lifestyle changes

The experts at TCT (Testosterone Centers of Texas) can help determine if semaglutide is suitable for you and provide guidance on its proper use, potential side effects, and monitoring requirements. 

As researchers continue to study semaglutide’s long-term cardiac health benefits and safety, the outlook for this medication remains promising in achieving sustainable weight loss and improved cardiovascular health.

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(Augie) Juan Augustine Galindo Jr. MPAS, PA-C

(Augie) Juan Augustine Galindo Jr. MPAS, PA-C started his career in healthcare as a fireman/paramedic in West Texas where he served on the Midland Fire Department from 1998-2004.   He became interested in testosterone treatment after seeing how hormone replacement doctors helped those suffering from low testosterone.   After graduating from the Texas Tech Health Sciences Center Physician Assistant Program, he moved to DFW where he currently lives with his wife and three children.

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