7 Progesterone Deficiency Symptoms (and What You Really Need to Know About Progesterone Deficiency)

Coming up with a comprehensive list of progesterone deficiency symptoms is tougher than you might think.

Progesterone Deficiency Symptoms

The reason? Progesterone is so closely associated with the action of other hormones that separating specific symptoms (and which deficiency is causing which) is quite difficult.

Progesterone, along with estrogen, is considered one of two so-called, “female hormones.” Of course, the reality is much more complex.

When I talk about estrogen, I’m not talking about just one chemical, but rather a group of chemicals that are structured similarly and have similar actions throughout the body.

Similarly, progesterone is part of a larger group of chemicals. It’s usually thought of as a “precursor hormone,” that your body uses to build other hormones. The main use of progesterone is to prepare your body for pregnancy.

This is actually the basis of many different birth control medications, and the reason why they work so well—they convince your body that it’s pregnant already (so there’s no need to ovulate).

Testosterone and estrogen receive the most attention in the world of hormone replacement therapy, but the action of progesterone may be just as important.

The relegation of progesterone to the back of the hormone line isn’t just happening at the clinical level. Even experienced, knowledgeable medical researchers are making the exact same mistakes, as you can see in this article.

It’s a persistent problem, so pinning down precise progesterone deficiency symptoms is tough. While I’m going to give you a list of possible symptoms here in a moment, I want you to keep in mind that there’s only one way to really know if you’re suffering from progesterone deficiency:

Get your progesterone levels tested.

Even Testing Progesterone Doesn’t Give Us the Whole Story

The problem is, everyone’s body is different. I write about this a lot, but I can’t stress it enough—what’s low for you isn’t low for someone else, and vice versa.

All we have are generalized standards to go on, but it’s what your body is doing (and how you’re feeling) that matters.

If I test your progesterone levels and find that they don’t meet the standards, that they aren’t what we would normally consider low, but, we find that you’re experiencing symptoms, then it doesn’t matter what the levels are at, because they’re low for your body.

But, ultimately, there are better times than others to look into what is going on with your progesterone/estrogen balance. Typically, I want to see these levels during your “mid-luteal phase.” This is the middle of the second half of your cycle, or roughly, 18-22 days after the start of your period or cycle.

Of course, we’re going to look at your other hormones as well—your progesterone deficiency symptoms may be low testosterone or low estrogen in disguise. In fact, we sometimes find that, for women, it’s their testosterone levels that are the problem (instead of the estrogen they thought was the culprit).

Also, we can see problems like “estrogen dominance,” which causes symptoms of high estrogen levels without actually having an elevated value. This happens because estrogen needs to be balanced out with other hormones, meaning symptoms that are typically synonymous with estrogen excess (like bloating, moodiness, fluid retention, etc.) can actually be due to progesterone deficiency and the resultant “failure of opposition.”

For men, we sometimes find that the problem wasn’t low testosterone at all, but rather had more to do with their estradiol levels.

It’s more likely that you have an imbalance of multiple hormones (rather than just one).

Once we have a good idea of the possible cause of your symptoms, then we can begin treatment. We work to bring all your hormones back into alignment, which can take time.

7 Common Progesterone Deficiency Symptoms

Here are some common progesterone deficiency symptoms:

  • Difficulty maintaining sleep
  • Symptoms of estrogen excess despite “normal” estrogen levels
  • Anxiety
  • Depression
  • Abnormal weight gain
  • Inability to lose weight
  • Fatigue
  • Headaches
  • Joint or muscle pain
  • Sensitivity to touch
  • Lack of interest in sex
  • Abnormal periods
  • Infertility

As you can see, these symptoms are quite similar to the symptoms of low testosterone in women. It can be hard to be sure what you’re really suffering from.

But I know you’re suffering.

Fortunately, there is a solution.

If you’re in the Dallas Fort Worth area, click here to contact us about an initial consultation.

Your initial consultation is free.

I look forward to hearing from you.

—Augie Galindo, PA-C


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(Augie) Juan Augustine Galindo Jr. MPAS, PA-C

(Augie) Juan Augustine Galindo Jr. MPAS, PA-C started his career in healthcare as a fireman/paramedic in West Texas where he served on the Midland Fire Department from 1998-2004.   He became interested in testosterone treatment after seeing how hormone replacement doctors helped those suffering from low testosterone.   After graduating from the Texas Tech Health Sciences Center Physician Assistant Program, he moved to DFW where he currently lives with his wife and three children.


  1. Edgar on 06/17/2016 at 12:16 pm

    Hi, I have a question about my fertility.

    • Augie Galindo on 06/20/2016 at 3:24 pm


      I will be happy to answer what I can!

      Best regards,
      Augie Galindo MPAS, PA-C
      Testosterone Centers of Texas | Founding Partner

  2. Krisha on 05/28/2017 at 5:44 am

    I live in oklahoma
    I had mirena iud for 17 months
    I had insomnia started a month after placement of mirena it got so worse that its followed by severe anxiety fogginess of brain and fatigue
    I am physician with small kids I struggled through this and didn’t realize till late iud might be causing these had it removed a year ago
    I still can not sleep well small things cause severe anxiety and insomnia
    I would like to come for consultation
    I can do labs here
    Please suggest what labs I need to get before I come see you for consult

    • Augie Galindo on 06/19/2017 at 9:46 pm


      It would be best if we talk in person, please contact the clinic and we can possibly arrange a consultation from there.

      Best regards,
      Augie Galindo MPAS, PA-C
      Testosterone Centers of Texas | Founding Partner

  3. Mary Scoville on 08/06/2017 at 3:27 pm

    What do you usually rec as optimal level of progesterone and do you prescribe the bioidentical pills..do you usually use 100,200 or 300 the most for women with low progesterone? Thanks

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